Antinociceptive activity of aqueous extract of Lepidium Sativum L. in mice

Hülya Özdemir, Biljana Yaren, Gökhan Oto
1.967 442

Abstract


Antinociceptive activity of aqueous extract of Lepidium Sativum L. in mice

 

Abstract

 

Purpose: In the present study the aqueous extract of Lepidium Sativum L. (family: Brassicaceae) was investigated for possible antinociceptive effect in Swiss - albino male mice.

Material and Methods: In this experiment three groups of male mice were used (n=6). Two models were used to study the effects of the extracts on nociception, acetic acid-induced writhing test and hot plate test in mice. Lepidium Sativum extract was administered in the dose of 20 mg/kg orally 30 minutes prior to pain induction.

Results: The aqueous extract showed significant (p < 0.05) analgesic activity evidenced by increase in the reaction time by hot plate method and significant (p < 0.05) reduction in acetic acid - induced writhings in mice with a maximum effect of 27.00 % reduction. These effects were compared with the control and standard drug, diclofenac sodium (50 mg/kg, p.o).

Conclusion: The results indicate that aqueous extract of Lepidium Sativum possesses a significant antinociceptive activity in central and peripheral pain models in mice and therefore, it can be used as supplemental therapy in acute or chronic pain conditions.

 

Keywords: Antinociception, aqueous extract, Lepidium Sativum L., Hot plate, Writhing test.


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